Dr. Han Shuwen from the School of Pharmaceutical Sciences has recently published a review article titled “Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review” in the top journal Green Synthesis and Catalysis, a Q1 journal under the Chinese Academy of Sciences. Taizhou University is listed as the primary contributing institution. Dr. Han Shuwen, recently recruited by the School of Pharmaceutical Sciences, is the first author. The paper’s co-corresponding authors include Academician Chen Fen’er (Department of Chemistry, Fudan University), Professor Shao Liming (School of Pharmaceutical Sciences, Fudan University; a visiting PI jointly affiliated with TU’s Institute for Advanced Research/School of Pharmaceutical Sciences), and Professor Hu JinFeng from TU.
The first page of the article
Organofluorine compounds containing two fluorine atoms, possessing distinct physical, chemical, and biological characteristics, have become crucial contributors to advancements in pharmaceutical development, agricultural chemistry, and material engineering. These structural modifications profoundly influence critical parameters including drug metabolism characteristics, molecular interaction strengths, and therapeutic effectiveness during pharmaceutical optimization processes. Contemporary research has increasingly focused on developing efficient synthesis strategies for difluorinated architectures, driven by their expanding applications in bioactive molecule design and therapeutic agent development. Recent studies highlight remarkable progress in creating novel fluorination methodologies, with particular emphasis on stereoselective incorporation and regiocontrolled installation of fluorine atoms in complex molecular frameworks.
Scheme 1. Visible-light-mediated difluoroalkylation reactions employing ethyl bromodifluoroacetate
Ethyl bromodifluoroacetate, as a key difluoroalkyl reagent, plays a significant role in organic synthesis and has been extensively employed for the incorporation of difluoromethyl groups into the diverse molecular skeleton. This review comprehensively summarizes the recent progress in visible-light-mediated difluoroalkylation reactions employing ethyl bromodifluoroacetate.
Link to the article: https://doi.org/10.1016/j.gresc.2025.07.008
